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[Clinical characteristics of patients with infection due to Influenza A (H1N1) 2009 and critical pathology]

J L Pérez Navero1, J Rumbao Aguirre, A Correas Sánchez

  • 1Intensivos Pediátricos, Unidad de Gestión Clínica de Pediatría y sus Especialidades, Hospital Universitario Reina Sofia, Córdoba, Spain. ucip.hrs.sspa@juntadeandalucia.es

Anales De Pediatria (Barcelona, Spain : 2003)
|January 4, 2011
PubMed

Insights

Children with risk factors face a higher risk of severe outcomes from Influenza A (H1N1), particularly those needing intensive care. Monitoring RT-PCR for Influenza A (H1N1) can guide isolation duration.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Critical Care Medicine

Context:

  • Influenza A (H1N1) caused significant pediatric hospitalizations during the 2009-2010 season.
  • Intensive therapy was required for a subset of these hospitalized children.

Purpose:

  • To analyze risk factors, clinical presentation, and outcomes of children hospitalized with Influenza A (H1N1).
  • To compare critically ill children (Group I) with non-critically ill hospitalized children (Group II).

Summary:

  • The study included 38 children, with 6 requiring intensive care. Critically ill patients had a higher prevalence of risk factors and respiratory symptoms.
  • Complications included ARDS, myocarditis requiring ECMO, and multi-organ dysfunction. Mortality was higher in the intensive care group.
  • Oseltamivir treatment duration and RT-PCR negativity time were longer in critically ill patients.

Impact:

  • Identifies risk factors associated with severe Influenza A (H1N1) in children.
  • Highlights the increased mortality and complications in critically ill pediatric patients.
  • Suggests RT-PCR monitoring can inform isolation protocols for Influenza A (H1N1).
Abstract

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