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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

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Effects of parenteral nutrition formulas on plasma lipid profile in children with bone marrow transplantation

M A Baena-Gómez1, M J de la Torre Aguilar, M D Mesa

  • 1Department of Paediatrics, Reina Sofia University Hospital, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.

Annals of Nutrition & Metabolism
|August 24, 2013
PubMed

Insights

Parenteral nutrition (PN) using fish oil or soybean oil is safe for children undergoing bone marrow transplantation (BMT). Soybean oil reduced HDL cholesterol and apo A more than fish oil, which increased omega-3 fatty acids.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Hematology

Background:

  • Parenteral nutrition (PN) is frequently required for pediatric patients undergoing bone marrow transplantation (BMT).
  • The lipid profile in these vulnerable patients can be significantly impacted by the type of PN used.

Purpose of the Study:

  • To compare the plasma lipid profiles in pediatric BMT patients receiving parenteral nutrition with either fish oil (ω3-enriched) or soybean oil-based lipid emulsions.
  • To assess the safety and impact on fatty acid composition of different lipid emulsions in BMT children.

Main Methods:

  • A randomized controlled trial involving 14 pediatric BMT patients requiring PN for at least 10 days.
  • Patients received either an ω3-enriched lipid emulsion or a standard soybean oil emulsion.
  • Plasma lipid profiles and fatty acid composition were analyzed before and after PN administration.

Main Results:

  • Both ω3-enriched and soybean oil PN were safe and well-tolerated in BMT children.
  • Soybean oil PN led to a greater decrease in HDL cholesterol (cHDL) and apolipoprotein A (apo A) compared to ω3-enriched PN.
  • ω3-enriched PN increased eicosapentaenoic acid and decreased arachidonic acid levels, while linolenic acid levels remained similar between groups.

Conclusions:

  • Parenteral nutrition with soybean or ω3-enriched emulsions for 10 days is safe in pediatric BMT patients.
  • Further research is needed to evaluate the long-term effects of PN duration and lipid formula type on the fatty acid profile and health benefits in children.
Abstract

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