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Updated: Jun 5, 2026
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Why YPEL3 represents a novel tumor suppressor.
Steven J Berberich1, Amber Todd, Rebecca Tuttle
1Biochemistry and Molecular Biology Department, Wright State University, Boonshoft School of Medicine, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA.
Yippee-like 3 (YPEL3) is a tumor suppressor gene induced by p53. This growth-suppressive protein triggers senescence and is downregulated in tumors, suggesting its role in cancer development.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Yippee-like 3 (YPEL3) is one of five Yippee protein family members.
- YPEL3 was identified as being induced by the p53 tumor suppressor.
- YPEL3 is growth suppressive, induces cellular senescence, and is downregulated in human tumors.
Purpose of the Study:
- To review the role of YPEL3 as a tumor suppressor.
- To investigate the regulation of YPEL3 gene expression.
- To explore the impact of YPEL3 on tumorigenesis.
Main Methods:
- Review of existing literature on YPEL3.
- Analysis of YPEL3 induction by p53 and its family members (p73, p63).
- Examination of YPEL3's growth suppressive and senescence-inducing properties.
Main Results:
- YPEL3 is transactivated by transcriptionally active forms of p73 and p63.
- Studies confirm YPEL3 encodes a growth suppressive, unstable protein (mouse YPEL3/SUAP).
- Evidence indicates YPEL3 functions as a tumor suppressor gene.
Conclusions:
- YPEL3 plays a significant role in tumor suppression.
- Further research is needed to understand YPEL3's biological function, gene regulation, and impact on cancer.
- Understanding YPEL3 is crucial for cancer research and therapeutic development.
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