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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

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Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
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Dentin: structure, composition and mineralization.

Michel Goldberg1, Askok B Kulkarni, Marian Young

  • 1UMR-S 747, INSERM, Universite Paris Descartes, Paris, France. michel.goldberg@parisdescartes.fr

Frontiers in Bioscience (Elite Edition)
|January 4, 2011
PubMed
Summary

This review details mammalian dentin types, odontoblast roles in dentinogenesis, and extracellular matrix (ECM) functions. It explores how ECM molecules promote or inhibit mineralization and signal during tooth formation.

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Area of Science:

  • Dentistry
  • Developmental Biology
  • Biochemistry

Background:

  • Mammalian teeth feature diverse dentin types, including mantle, circumpulpal, intertubular, and peritubular dentin.
  • Dentin formation involves physiological processes (primary, secondary) and pathological responses (reactionary dentin).

Purpose of the Study:

  • To review dentin types and their specificities in mammalian teeth.
  • To evaluate the role of odontoblasts in dentin formation, including collagen and non-collagenous molecule synthesis.
  • To study the composition and functions of dentin extracellular matrix (ECM) molecules in dentinogenesis.

Main Methods:

  • Literature review of dentin structures and formation processes.
  • Analysis of odontoblast function in synthesizing and secreting dentin components.
  • Examination of ECM molecule roles as structural proteins and signaling molecules.

Main Results:

  • Dentin comprises distinct layers and types, each with unique formation characteristics.
  • Odontoblasts are crucial for synthesizing type I collagen and non-collagenous ECM molecules.
  • ECM molecules act as mineralization regulators and signaling factors in dentinogenesis.
  • Three dentinogenesis forms identified: matrix vesicle-mediated, collagen/proteoglycan-driven predentin formation, and peritubular dentin development.

Conclusions:

  • Understanding dentin types, odontoblast function, and ECM composition is key to comprehending dentinogenesis.
  • Dentin ECM molecules play multifaceted roles in mineralization and signaling during tooth development.
  • The study clarifies distinct pathways contributing to different dentin formations.