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Updated: Jan 25, 2026

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
Published on: November 2, 2021
Sublancin is not a lantibiotic but an S-linked glycopeptide
Trent J Oman1, John M Boettcher, Huan Wang
1Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Abstract:
Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.
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