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Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
Published on: January 29, 2020
Amphibians as research models for regenerative medicine
Fengyu Song1, Bingbing Li, David L Stocum
1Department of Oral Pathology, Indiana University School of Dentistry, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Abstract:
The ability to regenerate bone across a critical size defect would be a marked clinical advance over current methods for dealing with such structural gaps. Here, we briefly review the development of limb bones and the mandible, the regeneration of urodele limbs after amputation, and present evidence that urodele and anuran amphibians represent a valuable research model for the study of segment defect regeneration in both limb bones and mandible.
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