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Updated: Jun 5, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Testosterone and growth hormone normalization: a retrospective study of health outcomes
Enrique Ginzburg1, Alvin Lin, Michael Sigler
1University of Miami Miller School of Medicine, Miami, Florida, USA.
Background:
Age-related declines in testosterone and growth hormone (GH) are associated with increased adiposity and decreases in lean mass and bone mineral density (BMD). A long-term retrospective study examined the effects of testosterone and/or GH supplementation on body composition and quality of life (QoL).
Methods:
A database survey assessed the records of 91 men and 97 women (ages 25-82) in treatment groups based on their hormonal status: dehydroepiandrosterone but no hormonal supplementation (control); testosterone only (Tes); GH only (GH); and testosterone plus GH (Tes+GH). Pre-and post-treatment assessments recorded changes in fat and lean mass, BMD, and QoL.
Results:
After an average of 3 years of treatment, weight decreased in women in the control and Tes+GH groups but remained stable in men in all groups. Tes and Tes+GH produced statistically significant increases in lean mass, reductions in fat mass, and improvements in BMD in both sexes; GH produced similar changes in women. QoL and mood improved in all groups. Treatments were generally safe and well tolerated.
Conclusions:
In this retrospective survey, treatment with testosterone and/or GH was associated with favorable effects in men and women across a wide age range.
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