[Combination of a carbon dioxide bath and a diuretic--follow-up study of several days]

A series of 22 men underwent a 30 minute carbon dioxide bath and was simultaneously administered Hydrochlorothiazide SPOFA. Their renal response was studied, and that both separately to the bath or the diuretic and to their combination. Diuresis was increased by 200 l x 10(-3) after the carbon dioxide bath and by 500 l x 10(-3) after hydrochlorothiazide. This increase was even further enhanced after the combination of the two treatments. Sodium excretion showed a similar increase, whereas kaliuresis did not exhibit such a marked rise and the differences between the response to the bath and to the diuretic were small. Repeated combination of the carbon dioxide bath and the diuretic resulted in a slightly increasing diuresis over the days studied. The authors emphasize the necessity to understand the bath--drug interactions particularly in balneological practice and substantiate the advantage and usefulness of the combination studied in indicated cases.