Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and autoantibody associations with malignancy in systemic sclerosis: A systematic review and meta-analysis.

Rheumatology (Oxford, England)·2026
Same author

Incidence of malignancy in systemic sclerosis: A systematic review and meta-analysis.

Seminars in arthritis and rheumatism·2026
Same author

Co-designing interventions for patients with inflammatory arthritis: a systematic review.

Systematic reviews·2026
Same author

Myocardial Infarction Without Standard Modifiable Risk Factors From 2025-2040: Forecast Analysis of Multinational, Population-Based Study.

JACC. Asia·2026
Same author

Recommendations for screening for latent tuberculosis infection in people with rheumatic diseases: Consensus statement from the Singapore Chapter of Rheumatologists.

Annals of the Academy of Medicine, Singapore·2026
Same author

Preliminary insights into artificial intelligence guided dosing in hypertension and diabetes: challenges and lessons learnt in a pilot feasibility study.

JAMIA open·2026

Related Experiment Video

Updated: Jun 5, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

The autoimmunity conundrum: clotting or inflammation.

Dennis Z Y Yee1, Gim Gee Teng, Anita Y N Lim

  • 1Division of Rheumatology, Department of Medicine, National University Heath System, Singapore.

International Journal of Rheumatic Diseases
|January 5, 2011
PubMed
Summary

Antiphospholipid syndrome (APS) can mimic infective endocarditis, presenting with valve vegetations. Early recognition of APS is crucial for distinct treatment strategies compared to systemic lupus erythematosus.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Area of Science:

  • Rheumatology
  • Cardiology
  • Internal Medicine

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder with diverse clinical effects.
  • It can manifest in cardiovascular, neurological, renal, and cutaneous systems, alongside thrombocytopenia.

Observation:

  • A young woman presented with fever, cough, and dyspnea.
  • She had a history of recurrent pregnancy losses and positive antiphospholipid and lupus serologies.
  • Echocardiography revealed mobile mitral and aortic valve vegetations.

Findings:

  • The patient was initially treated for infective endocarditis.
  • She was diagnosed with primary APS presenting with a lupus-like disease.
  • The case highlights the potential for APS to mimic infective endocarditis.

Implications:

  • Vigilance is needed to identify underlying rheumatological conditions in patients with suspected infective endocarditis lacking typical risk factors.
  • Distinguishing between primary APS and systemic lupus erythematosus is vital as treatments differ significantly.
  • This case underscores the importance of comprehensive serological evaluation in unexplained cardiac findings.