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Updated: Jun 5, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Pyrimidine-2-carboxamide
Bing-Yu Zhang1, Qian Yang, Jing-Jing Nie
1Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Abstract:
In the crystal strucuture of the title compound, C(5)H(5)N(3)O, which was obtained upon recrystallization of 2-cyano-pyrimidine from aqueous sodium hydroxide, the amide group is twisted with respect to the aromatic ring by 24.9 (1)°. π-π stacking is observed between partially overlapped rings at a face-to-face separation of 3.439 (6) Å. The structure features a centrosymmetric pair of inter-molecular N-H⋯O hydrogen bonds. Another N-H⋯O hydrogen bond between adjacent mol-ecules links them into a helical chain motif.
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