Related Experiment Video

Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

2-(2,3,5,6-Tetra-fluoro-4-iodo-anilino)-ethanol

Pierangelo Metrangolo, Franck Meyer, Tullio Pilati

    Acta Crystallographica. Section E, Structure Reports Online
    |January 5, 2011
    PubMed

    More Related Videos

    Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes09:54

    Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

    Published on: September 12, 2018

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors09:45

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Related Concept Videos

    Acidity and Basicity of Alcohols and Phenols02:36

    Acidity and Basicity of Alcohols and Phenols

    Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
    Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis02:29

    Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

    Overview
    Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
    Preparation of Ethers by Alcohol Dehydration
    In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
    Protection of Alcohols02:31

    Protection of Alcohols

    This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
    Protection
    It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
    Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

    Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

    Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
    Structure and Nomenclature of Ethers02:28

    Structure and Nomenclature of Ethers

    Structure and Bonding
    Ethers are organic compounds with an ether functional group which is characterized by an oxygen atom connected to two — identical or different — alkyl, aryl, or vinyl groups. The C–O–C linkage in dimethyl ether — the simplest ether — has an approximately tetrahedral bond angle of 110.3 degrees. The oxygen atom is sp3- hybridized, with the C–O distance being about 140 pm.
    Classification of Ethers
    Based on their attached substituent groups, ethers can be classified into two...
    Structure and Nomenclature of Alcohols and Phenols02:23

    Structure and Nomenclature of Alcohols and Phenols

    Overview
    Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
    As with other organic compounds, alcohols and phenols...