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Related Experiment Video

Updated: Jun 5, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

l-Nebiviololinium chloride dihydrate.

Gisbert Tuchalski, Andre Hänsicke, Günther Reck

    Acta Crystallographica. Section E, Structure Reports Online
    |January 5, 2011
    PubMed
    Summary

    Chiral l-nebivolol hydrochloride dihydrate was isolated using chiral liquid chromatography. Its crystal structure reveals specific pyran ring conformations and layered structures formed by hydrogen bonds.

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Pharmaceutical Science

    Background:

    • Nebivolol is a beta-blocker used to treat hypertension.
    • Chiral separation is crucial for isolating specific enantiomers of drugs.
    • Understanding the solid-state structure of drug molecules is important for formulation and stability.

    Purpose of the Study:

    • To characterize the hydro-chloride salt of chiral l-nebivolol.
    • To determine the crystal structure of the dihydrate form.
    • To investigate the intermolecular interactions within the crystal lattice.

    Main Methods:

    • Chiral liquid chromatography for enantiomeric separation.
    • Single-crystal X-ray diffraction for structural determination.
    • Analysis of hydrogen bonding and molecular conformation.

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    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
    04:38

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

    Published on: July 28, 2022

    Related Experiment Videos

    Last Updated: Jun 5, 2026

    An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
    12:02

    An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

    Published on: November 2, 2016

    Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
    11:04

    Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

    Published on: June 13, 2022

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
    04:38

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

    Published on: July 28, 2022

    Main Results:

    • The hydro-chloride salt of chiral l-nebivolol was obtained as a dihydrate.
    • The pyran rings within the molecule adopt half-chair conformations.
    • Layered crystal structures were observed, stabilized by hydrogen bonds between the cation, anions, and water molecules.

    Conclusions:

    • The study provides a detailed structural characterization of chiral l-nebivolol hydrochloride dihydrate.
    • The findings contribute to the understanding of nebivolol's solid-state properties.
    • This structural information can aid in pharmaceutical development and quality control.