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Updated: Dec 29, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
2-Meth-oxy-N'-(2-methoxy-benzyl-idene)benzohydrazide
Jiu-Fu Lu1, Suo-Tian Min, Xiao-Hui Ji
1School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong 723000, People's Republic of China.
This study synthesized a novel Schiff base compound, C(16)H(16)N(2)O(3), via condensation. The crystal structure reveals a significant dihedral angle and intermolecular hydrogen bonding, forming molecular chains.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Schiff base compounds are versatile organic molecules with diverse applications.
- Understanding the structural properties of Schiff bases is crucial for their targeted synthesis and utilization.
Purpose of the Study:
- To synthesize and characterize a novel Schiff base compound.
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Condensation reaction between 2-methoxy-benzaldehyde and 2-methoxy-benzohydrazide in ethanol.
- Single crystal X-ray diffraction analysis to determine the molecular and crystal structure.
Main Results:
- The Schiff base compound, C(16)H(16)N(2)O(3), was successfully synthesized.
- The crystal structure exhibits a dihedral angle of 87.5(3)° between the two aromatic rings.
- Intermolecular N-H⋯O hydrogen bonds link molecules into chains parallel to the a-axis.
Conclusions:
- The synthesis and structural elucidation of the novel Schiff base were achieved.
- The observed crystal packing, stabilized by hydrogen bonds, influences the compound's solid-state properties.
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