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Updated: Jun 5, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
N-(3-Chloro-phen-yl)-2-methyl-benzamide
This study details the molecular conformation of a chloro-substituted benzamide derivative. N-H...O hydrogen bonds link molecules into chains, similar to related benzamide structures.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzamide derivatives are important in medicinal chemistry and materials science.
- Understanding molecular conformation is crucial for predicting chemical properties and biological activity.
Purpose of the Study:
- To elucidate the crystal structure and molecular conformation of a novel chloro-substituted benzamide.
- To compare the observed conformation with that of a similar known compound, 2-methyl-N-(3-methyl-phen-yl)benzamide (N3MP2MBA).
Main Methods:
- Single-crystal X-ray diffraction was used to determine the three-dimensional structure.
- Analysis of bond orientations, dihedral angles, and intermolecular interactions (hydrogen bonding).
Main Results:
- The N-H bond is anti to the meta-chloro substituent, and the C=O bond is syn to the ortho-methyl substituent.
- The -NHC(=O)- group has a dihedral angle of 55.8(7)° with the benzoyl ring, and the inter-ring angle is 37.5(1)°.
- Infinite chains of molecules linked by N-H⋯O hydrogen bonds were observed along the c axis.
Conclusions:
- The molecular conformation is similar to N3MP2MBA, indicating conserved structural motifs in related benzamides.
- The observed hydrogen bonding pattern influences the crystal packing and supramolecular assembly.
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