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Updated: Jun 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Cholic acid-quinoxaline (2/1).

Barbara Wicher¹, Maria Gdaniec

¹Faculty of Chemistry, Adam Mickiewicz University, 60-780 Poznań, Poland.

Acta Crystallographica. Section E, Structure Reports Online

|January 5, 2011

Summary

Cholic acid forms bilayers that encapsulate quinoxaline molecules within lipophilic channels. This crystal structure reveals a unique 1:1 superposition of guest molecules within the host framework.

Area of Science:

Crystal Engineering
Supramolecular Chemistry
Materials Science

Background:

Cholic acid, a bile acid, exhibits amphiphilic properties.
Self-assembly of amphiphiles can form ordered structures.
Inclusion compounds involve host-guest interactions.

Purpose of the Study:

To characterize the crystal structure of a cholic acid-quinoxaline inclusion compound.
To understand the self-assembly behavior of cholic acid in the presence of quinoxaline.
To elucidate the host-guest interactions and packing arrangements.

Main Methods:

Single-crystal X-ray diffraction analysis.
Analysis of hydrogen bonding and intermolecular interactions.
Space group determination and unit cell analysis.

Related Experiment Videos

Last Updated: Jun 5, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Main Results:

The crystal structure consists of cholic acid bilayers and disordered quinoxaline molecules.
Cholic acid molecules assemble via hydrogen bonds into corrugated bilayers.
Quinoxaline guests are located in lipophilic channels between bilayers, interacting via van der Waals forces.
A 1:1 superposition of two guest arrangements related by a twofold screw axis was observed.

Conclusions:

Cholic acid forms a stable host framework capable of encapsulating guest molecules.
The structure demonstrates a specific type of host-guest complexation driven by amphiphilic self-assembly.
The observed disorder and superposition of guest molecules provide insights into crystal packing and guest mobility.