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Updated: Jan 16, 2026
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Solvated forms of carbenoxolone - different degrees of structural similarities
Bartłomiej Kobus1, Zuzanna Spychała1, Oliwia Kleybor1
1Poznan University of Medical Sciences, Department of Chemical Technology of Drugs, Rokietnicka 3, Poznan, 60-806, Poland.
Abstract:
Carbenoxolone (CBXH2) is a biologically active compound first synthesized in the late 1950s. Four new solvates of CBXH2 with propan-1-ol, tert-butanol, dimethylformamide and dimethyl sulfoxide were obtained and characterized using single-crystal and powder X-ray diffraction along with thermal analyses. Ribbons and layers, recurring building motifs in these structures, are primarily based on dispersion interactions. The degree of similarity (1D, 2D or 3D) between these new structures and four CBXH2 structures from the Cambridge Structural Database was evaluated using geometrical parameters and XPac calculations.
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