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Updated: Jun 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl N'-[(E)-4-hydr-oxy-3-methoxy-benzyl-idene]hydrazinecarboxyl-ate
1Zhejiang Police College Experience Center, Zhejiang Police College, Hangzhou 310053, People's Republic of China.
Abstract:
The mol-ecule of the title compound, C(10)H(12)N(2)O(4), adopts a trans configuration with respect to the C=N double bond. The dihedral angle between the benzene ring and the hydrazinecarboxyl-ate mean plane is 36.54 (6)°. The mol-ecules are linked into a two-dimensional network by inter-molecular O-H⋯O, N-H⋯O and O-H⋯N hydrogen bonds, and by aromatic π-π stacking inter-actions [ring-centroid separation 3.7689 (9) Å].
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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Carbocations

