Related Experiment Video
Updated: Jun 5, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
1-(2-Furo-yl)-3-(o-tol-yl)thio-urea
Abstract:
The title compound, C(13)H(12)N(2)O(2)S, was synthesized from furoyl isothio-cyanate and o-toluidine in dry acetone. The thio-urea group is in the thio-amide form. The central thio-urea fragment makes dihedral angles of 2.6 (1) and 22.4 (1)° with the ketofuran group and the benzene ring, respectively. The mol-ecular structure is stabilized by N-H⋯O hydrogen bonds. In the crystal structure, centrosymmetrically related mol-ecules are linked by a pair of N-H⋯S hydrogen bonds to form a dimer with an R(2) (2)(6) ring motif.
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