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Calmodulin-dependent Signaling

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Related Experiment Video

Updated: Jun 5, 2026

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions
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Published on: May 5, 2018

Antalarmin.

Stephen R Slauson, John M Rimoldi, Frank R Fronczek

    Acta Crystallographica. Section E, Structure Reports Online
    |January 5, 2011
    PubMed
    Summary

    This study details the molecular structure of N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. The research reveals a nearly planar pyrrolopyrimidine core with an orthogonal benzene ring and a flattened pyramidal nitrogen atom.

    Area of Science:

    • Organic Chemistry
    • Crystallography
    • Molecular Structure Analysis

    Background:

    • Pyrrolopyrimidine derivatives are significant scaffolds in medicinal chemistry.
    • Understanding the precise three-dimensional structure of novel compounds is crucial for structure-activity relationship studies.

    Purpose of the Study:

    • To elucidate the crystal structure of N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.
    • To analyze the planarity and spatial arrangement of the pyrrolopyrimidine core and its substituents.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was performed on the title compound.
    • The molecular geometry, including bond lengths, bond angles, and dihedral angles, was determined.

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    Main Results:

    • The pyrrolopyrimidine ring system exhibits near planarity, with a dihedral angle of 5.3(2)° between the fused five- and six-membered rings.
    • The pendant 2,4,6-trimethyl-phenyl group is positioned nearly orthogonal to the central heterocyclic system.
    • The nitrogen atom bearing the N-butyl and N-ethyl substituents displays a flattened pyramidal geometry.

    Conclusions:

    • The detailed structural analysis provides fundamental insights into the conformational preferences of this substituted pyrrolopyrimidine.
    • These findings can aid in the rational design of new pyrrolopyrimidine-based molecules with tailored properties.