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Lensfree sensing on a microfluidic chip using plasmonic nanoapertures.

Bahar Khademhosseinieh, Gabriel Biener, Ikbal Sencan

    Applied Physics Letters
    |January 5, 2011
    PubMed
    Summary

    This study introduces lensfree on-chip sensing using plasmonic nanoapertures for precise refractive index detection. This method advances label-free microarray technologies for high-throughput sensing applications.

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    Area of Science:

    • Plasmonics
    • Microfluidics
    • Optical Sensing

    Background:

    • Traditional sensing methods often require complex optical setups.
    • Microfluidic devices offer miniaturization but require sensitive detection techniques.
    • Plasmonic nanoapertures exhibit unique optical properties for enhanced sensing.

    Purpose of the Study:

    • To demonstrate a lensfree on-chip sensing technique using plasmonic nanoapertures.
    • To achieve label-free detection of local refractive index changes.
    • To explore the potential for high-throughput microarray technologies.

    Main Methods:

    • Utilizing plasmonic nanoapertures within a microfluidic channel.
    • Illuminating the nanoapertures with a partially coherent quasimonochromatic source.

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  • Recording lensfree diffraction patterns with an optoelectronic sensor-array.
  • Applying phase recovery techniques for digital focusing and complex transmission pattern generation.
  • Employing cross-correlation for refractive index sensing.

    • Main Results:

    • Successfully demonstrated lensfree on-chip sensing of refractive index.
    • Achieved detection of refractive index changes as small as approximately 2x10^-3.
    • Validated the capability of the technique for label-free sensing.

    Conclusions:

    • Lensfree on-chip sensing with plasmonic nanoapertures is a viable and sensitive detection method.
    • This approach enables label-free sensing within microfluidic systems.
    • The technology holds significant potential for developing high-throughput multiplexed microarray technologies.