Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invasive Lobular Carcinoma of the Male Breast With BRCA2 Mutation.

Case reports in pathology·2026
Same author

Small Bowel Neuroendocrine Tumors: An Update.

Archives of pathology & laboratory medicine·2025
Same author

Role of ERβ in Triple-Negative Breast Cancer Associated with p53 and Androgen Receptor.

International journal of molecular sciences·2025
Same author

Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Young Woman With Congenital HIV.

Cureus·2025
Same author

Fibroblast-specific targeting of bone morphogenetic protein signaling molecules does not alter the outcome of alcohol-associated chronic pancreatitis in mice.

Alcohol and alcoholism (Oxford, Oxfordshire)·2025
Same author

Targeting the hepatic circadian clock concomitant with tyrosine kinase inhibition reverses late-stage hepatocellular carcinoma.

Cell reports·2025

Related Experiment Video

Updated: Jun 5, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Estrogen receptor β.

Mamoun Younes1, Naoko Honma

  • 1Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. myounes@bcm.edu

Archives of Pathology & Laboratory Medicine
|January 6, 2011
PubMed
Summary
This summary is machine-generated.

Estrogen receptor beta (ER-B) is a newly identified protein with broader tissue distribution than estrogen receptor alpha. ER-B positivity in breast cancer correlates with improved survival in tamoxifen-treated patients.

More Related Videos

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Estrogen receptor beta (ER-B) was discovered in 1996, distinct from the previously known estrogen receptor alpha (ER-A).
  • ER-B exists in multiple isoforms with varied tissue distribution and potential functions.
  • ER-B expression in breast cancer is linked to improved patient survival, independent of ER-A status.

Purpose of the Study:

  • To review estrogen receptor beta (ER-B), focusing on its clinical relevance for pathologists.
  • To highlight the diagnostic and prognostic significance of ER-B in various cancers.

Main Methods:

  • Literature search of PubMed using keywords "estrogen receptor beta" and "immunohistochemistry."
  • Review of selected abstracts and articles emphasizing pathological relevance.
  • Synthesis of current knowledge on ER-B expression and clinical implications.

Main Results:

  • Estrogen receptor beta (ER-B) exhibits wider tissue distribution than ER-A, including the gastrointestinal tract, lung, and brain.
  • ER-B-positive breast cancers show a favorable outcome with adjuvant tamoxifen therapy, irrespective of ER-A expression.
  • The clinical significance of ER-B in non-breast tumors is an active area of research.

Conclusions:

  • Estrogen receptor beta (ER-B) is an important biomarker with potential clinical applications in oncology.
  • Pathologists should be aware of ER-B and its isoforms for accurate diagnosis and prognosis.
  • Further research is needed to fully elucidate the role of ER-B in various malignancies.