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Mild encephalitis/encephalopathy with a reversible splenial lesion: evaluation by diffusion tensor imaging. Two case

Satoru Osuka1, Hironori Imai, Eiichi Ishikawa

  • 1Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki.

Neurologia Medico-Chirurgica
|January 6, 2011
PubMed

Insights

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare condition. MRI studies show that while diffusion is altered, white matter structure remains intact during MERS, even after symptom resolution.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a distinct clinico-radiological syndrome.
  • Understanding the neuroimaging characteristics of MERS is crucial for diagnosis and prognosis.

Observation:

  • Three patients diagnosed with MERS underwent advanced magnetic resonance imaging (MRI) including diffusion tensor imaging (DTI).
  • Initial diffusion-weighted imaging (DWI) revealed reduced apparent diffusion coefficient (ADC) values within the splenial lesions.

Findings:

  • The observed reduction in ADC values in MERS lesions resolved completely as symptoms subsided.
  • Diffusion anisotropy (AD) within the lesions showed no significant abnormalities in either early or delayed phases.
  • These DTI findings suggest preserved white matter architecture in the affected area during MERS.

Implications:

  • The preserved white matter architecture indicated by DTI may explain the typically benign and reversible nature of MERS.
  • These findings contribute to a better understanding of the pathophysiology of MERS.
  • Advanced MRI techniques like DTI can offer valuable insights into reversible white matter lesions.

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