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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Markings01:26

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Intraosseous hibernoma.

Rajendra Kumar1, Michael T Deaver, Bogdan A Czerniak

  • 1Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA. rajkumar@mdanderson.org

Skeletal Radiology
|January 6, 2011
PubMed
Summary
This summary is machine-generated.

This study details a rare sacral hibernoma, a benign tumor, discovered incidentally. Imaging and biopsy confirmed it as brown adipose tissue, offering insights into rare bone tumors.

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Hibernomas are rare, benign tumors originating from brown adipose tissue.
  • Intraosseous hibernomas are exceptionally rare, with few documented cases.

Observation:

  • A patient presented with low back pain, and imaging revealed an incidental, sclerotic, intraosseous lesion in the sacrum.
  • CT showed a sclerotic lesion, while MRI demonstrated specific signal characteristics: heterogeneously hyperintense on T1W, heterogeneously hypointense on fat-saturated T2W/STIR, and mild enhancement post-contrast.

Findings:

  • Biopsy confirmed the lesion as a hibernoma, characterized by multivacuolated cells with immunohistochemical features of brown adipose tissue.
  • The imaging findings, particularly the MRI signal intensities and enhancement patterns, were consistent with hibernoma.

Implications:

  • This case expands the understanding of rare intraosseous hibernomas and their imaging features.
  • Accurate radiological diagnosis can potentially avoid unnecessary invasive procedures for benign bone lesions.