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Updated: Jun 5, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
The ABC's of stroke complications
W David Freeman1, Steven B Dawson, Kelly D Flemming
1Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA. freeman.william1@mayo.edu
Insights
Stroke complications significantly increase mortality and morbidity. Early diagnosis and prevention strategies for common issues like aspiration and deep vein thrombosis (DVT) are crucial for better patient outcomes.
Area of Science:
- Neurology
- Internal Medicine
- Critical Care Medicine
Background:
- Stroke is a leading cause of death in the U.S., responsible for over 140,000 annual fatalities.
- Post-stroke complications, arising from cerebral and extracerebral causes, frequently contribute to patient morbidity and mortality.
- Common cerebral complications include cerebral edema and infarct progression, while extracerebral issues involve deep vein thrombosis (DVT) and pulmonary embolism.
Purpose of the Study:
- To highlight common post-stroke complications.
- To emphasize the importance of recognizing and managing these complications.
- To underscore the role of preventive strategies in improving patient outcomes.
Main Methods:
- Review of common post-stroke complications.
- Focus on aspiration, deep vein thrombosis (DVT), decubitus ulcers, seizures, and urinary catheter infections.
- Discussion of preventable complications often monitored as quality metrics.
Main Results:
- Post-stroke complications are frequent and contribute to poor outcomes.
- Many complications, such as aspiration and DVT, are preventable.
- Effective management and prevention are key to reducing stroke-related morbidity and mortality.
Conclusions:
- Knowledge of potential post-stroke complications is vital for timely diagnosis.
- Implementing preventive strategies can significantly mitigate risks.
- Proactive management is essential for improving the quality of life for stroke survivors.
Abstract:
Stroke is the third leading cause of death in the United States, with more than 140,000 deaths per year. Complications related to stroke resulting in morbidity and mortality are very common and may result from cerebral and extracerebral causes. Cerebral causes include cerebral edema, hemorrhagic conversion of an ischemic infarct, and progression of penumbra to infarction. Extracerebral complications include deep vein thrombosis and pulmonary embolism, urinary tract infection, and aspiration. Many of these complications are largely preventable and often tracked as "quality metrics" in institutions with a stroke center designation. The focus of the article is primarily on common poststroke complications, such as aspiration, DVT, decubitus ulcers, seizures, and urinary catheter infections. Knowledge about potential poststroke complications is critical to earlier diagnosis, proper preventive strategies, and management.
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