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Updated: Jun 14, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
Published on: May 23, 2011
Neurological complications in microgravity and long duration spaceflight
Giselle Coelho1, Alejandro Rabinstein2, W David Freeman3
1STR-X, Simulation Center, Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA. coelho.giselle@mayo.edu.
Abstract:
Long-duration spaceflight produces structural, functional, and hemodynamic brain changes driven by microgravity, radiation, elevated CO2, and isolation. Consequences include Spaceflight-Associated Neuro-Ocular Syndrome, vestibular imbalance, orthostatic intolerance, and cognitive disturbance. We consolidate current evidence, present a cerebrovascular physiologic framework, and discuss emerging countermeasures-including lower body negative pressure, artificial gravity, advanced neuromonitoring, and synthetic torpor-needed to safeguard neurological health on exploration-class missions.
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