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Updated: Jun 5, 2026
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
[The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats]
Xia Cao1, Xin-quan Gu, Shi-jie Yang
1Department of Phanmaology, Jilin University, Jilin Changchun 130021, China.
Aim:
To investigate the protective effects and mechanism of IPC on myocardial ischemia/reperfusion injury.
Methods:
Effects of IPC on arrhythmia and coronary blood flow and the release of AST, CPK, LDH, SOD and LFO at different time after ischemia/reperfusion injury in rat Langendorff hearts were studied.
Results:
IPC decreased the release of AST, CPK and LDH and increased myocardial SOD activity and decreased LPO level. IPC also inhibited ischemia/reperfusion arrhythmias and increased coronary blood flow.
Conclusion:
The results showed that IPC had well protective effects on myocardial ischemia/reperfusion injury.
