Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A case of resistant tuberculosis.

N Bhatti1, N Chronos, J P White

  • 1Department of Infectious Diseases, Northwick Park Hospital, Harrow, Middlesex, UK.

Tubercle
|June 1, 1990
PubMed
Summary

Treatment for drug-resistant pulmonary tuberculosis failed, even with ciprofloxacin. This case highlights challenges in managing extensively drug-resistant tuberculosis (XDR-TB) and the need for novel therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revolutionizing Pediatric Neurophysiology With Magnetoencephalography.

Psychophysiology·2026
Same author

Sagacity of surgical selectivity: a retrospective analysis of occlusal outcome and intermaxillary fixation use in midface fracture fixation.

The British journal of oral & maxillofacial surgery·2025
Same author

The CALERIE Genomic Data Resource.

Nature aging·2024
Same author

The CALERIE<sup>™</sup> Genomic Data Resource.

bioRxiv : the preprint server for biology·2024
Same author

Monkeypox presenting as a facial abscess.

British dental journal·2023
Same author

'Dear Doctor': a randomised controlled trial of a text message intervention to reduce burnout in trainee anaesthetists.

Anaesthesia·2022

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Microbiology

Background:

  • Tuberculosis (TB) remains a significant global health challenge, particularly drug-resistant forms.
  • Multiple drug-resistant tuberculosis (MDR-TB) requires complex and prolonged treatment regimens.
  • Extensively drug-resistant tuberculosis (XDR-TB) presents even greater therapeutic challenges.

Observation:

  • A case of pulmonary tuberculosis was documented with resistance to multiple drugs.
  • Two second-line chemotherapy regimens proved inadequate for treatment.
  • The patient remained sputum smear-positive for Mycobacterium tuberculosis despite treatment.

Findings:

  • In vitro susceptibility testing indicated sensitivity to ciprofloxacin.
  • Despite sensitivity and treatment, the patient did not achieve sputum conversion after 11 months.
  • This suggests potential challenges with in vitro to in vivo correlation or other factors influencing treatment efficacy.

Implications:

  • This case underscores the difficulties in treating MDR-TB and XDR-TB.
  • It highlights the limitations of current second-line therapies and the need for alternative treatment options.
  • Further research into novel anti-TB drugs and treatment strategies is crucial for improving patient outcomes.

Related Experiment Videos