Related Experiment Video
Updated: Aug 14, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Airway pressures during positive-pressure ventilation with superimposed oscillations
A Jonzon1, J A Tantalean, T Norsted
1Department of Pediatrics, University Hospital, Uppsala, Sweden.
Abstract:
This study was undertaken to determine whether oscillations superimposed on a regular ventilatory pattern influence the arterial blood gases and pH and the airway pressures at adequate alveolar ventilation at the onset of inhibition of inspiratory activity. The peak, mean and end-expiratory airway pressures were therefore measured at inhibition of this activity with and without superimposition of oscillations on the ventilatory pattern. It was found that superimposed oscillations lowered the airway pressure only at a low ventilatory frequency, whereas inhibition occurred at almost equal arterial PCO2 and pH values with and without superimposed oscillations on the ventilatory pattern.
Related Concept Videos
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

