Related Experiment Video
Updated: Jun 5, 2026

08:41
Mouse Round Spermatid Injection
Published on: January 26, 2024
Hsp90β1 knockout targeted to male germline: a mouse model for globozoospermia
Christophe Audouard1, Elisabeth Christians
1Centre de Biologie du Développement, Université Toulouse III, Toulouse, France.
Fertility and Sterility
|January 7, 2011
Abstract:
To study the role of Hsp90β1, an endoplasmic chaperone, we have built a conditional knockout by crossing Hsp90β1(flox/flox) with the Vasa-Cre transgenic line. Spermatozoa deficient in Hsp90β1 could not naturally fertilize oocytes and exhibited large and globular heads with abnormal intermediate pieces, a phenotype reminiscent of human globozoospermia.

