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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Acetate causes alcohol hangover headache in rats

Christina R Maxwell1, Rebecca Jay Spangenberg, Jan B Hoek

  • 1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

Plos One
|January 7, 2011
PubMed
Summary

Acetate accumulation, not acetaldehyde, contributes to hangover headaches. Blocking adenosine pathways may alleviate hangover-like hypersensitivity, offering new insights into headache mechanisms.

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