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Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Strong ion reserve: a viewpoint on acid base equilibria and buffering
1Second Department of Intensive Care Medicine, "Georgios Papanikolaou" General Hospital of Thessaloniki, 57010, Exochi, Greece. m.agrafiotis@gmail.com
European Journal of Applied Physiology
|January 7, 2011
Summary
The body
Area of Science:
- Biochemistry
- Physiology
Background:
- Strong ions, like electrolytes, can bind to proteins.
- This binding is influenced by pH levels.
- These ions can be released to influence the body's acid-base balance.
Purpose of the Study:
- To explore the role of protein-bound strong ions in buffering acid-base disturbances.
- To define the concept of a 'strong ion reserve' within biological systems.
Main Methods:
- Literature review and theoretical analysis of acid-base physiology.
- Examination of the pH-dependent binding of strong ions to proteins.
Main Results:
- Strong ions reversibly bind to proteins in a pH-dependent manner.
- Recruitment of these ions from proteins can modulate the strong ion difference.
- This process acts as a buffer against acid-base disturbances, representing a 'strong ion reserve'.
Conclusions:
- Protein-bound strong ions play a significant physiological role in maintaining acid-base homeostasis.
- The 'strong ion reserve' is a crucial concept for understanding the body's buffering capacity.
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