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Published on: September 25, 2009
Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report
Ju-Chun Yen1, Lung Chan, Yen-Jun Lai
1Section of Neurology, Department of Internal Medicine Far-Eastern Memorial Hospital, Taipei, Taiwan.
Purpose:
Migraine and artery dissection are both rare causes of ischemic stroke. The mechanism of migraine-related intracranial artery dissection is still unknown. It is proposed that the repeated attack of migraine would make the involved artery more vulnerable to tearing and lead to dissection.
Case Report:
We describe a 42-year-old female suffering from basilar-type migraine for more than 20 years. The patient complained severe dizziness with hyperventilation while watching television. Initially anxiety and migraine attack were impressed in the emergency room, but dizziness accompanied with dysarthria and dysphagia was noted later. After admission, lateral medullary syndrome was suspected after a detailed neurological examination, and a brain magnetic resonance image (MRI) revealed an acute infarction on the left lateral medulla oblongata, confirming the clinical diagnosis Furthermore, cerebral angiography revealed the left distal vertebral artery dissection. The patient was reluctant to use an anticoagulant; therefore aspirin was given for secondary stroke prevention and topiramate for migraine prophylaxis.
Conclusion:
The exact mechanism of migraine-related intracranial artery dissection has yet to be proven, we propose that this may be caused by vessel wall edematous changes with repeated migraine attacks resulting in sudden or unusual stretching.
Insights
Migraine attacks may predispose arteries to dissection, potentially causing ischemic stroke. This case highlights a link between basilar-type migraine and vertebral artery dissection, suggesting vessel wall changes as a possible mechanism.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroscience
Background:
- Migraine and intracranial artery dissection are rare causes of ischemic stroke.
- The mechanism linking migraine to intracranial artery dissection remains unclear.
- Repeated migraine attacks may increase artery vulnerability to dissection.
Observation:
- A 42-year-old female with a 20-year history of basilar-type migraine presented with dizziness.
- Neurological examination revealed lateral medullary syndrome.
- Brain MRI confirmed acute infarction in the left lateral medulla oblongata.
Findings:
- Cerebral angiography identified dissection of the left distal vertebral artery.
- The patient received aspirin for secondary stroke prevention and topiramate for migraine prophylaxis.
- This case suggests a potential association between migraine and vertebral artery dissection.
Implications:
- The findings suggest that vessel wall edematous changes from repeated migraine attacks may lead to dissection.
- This proposed mechanism involves sudden or unusual vessel stretching.
- Further research is needed to elucidate the exact mechanism of migraine-related intracranial artery dissection.
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