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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

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Shape-memory anchoring system for bladder sensors.

Iaci M Pereira1, Fabrice Axisa, Rodrigo L Oréfice

  • 1Brazilian Army Technological Center, Rio de Janeiro, Brazil. iacipere@yahoo.com.br

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|January 7, 2011
PubMed
Summary
This summary is machine-generated.

Shape-memory polymer anchors bladder sensors. This biodegradable material recovers shape at body temperature, potentially leading to sensor expulsion with urine due to degradation and bladder wall compression.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Developing effective anchoring systems for implantable bladder sensors is crucial for continuous monitoring.
  • Biocompatible and biodegradable materials are preferred for long-term in-vivo applications.
  • Shape-memory polymers offer unique properties for dynamic anchoring applications.

Purpose of the Study:

  • To develop and evaluate a novel shape-memory polymer anchoring system for bladder sensors.
  • To assess the material's properties, including degradation and shape recovery in a simulated physiological environment.
  • To investigate the potential for in-vivo sensor expulsion.

Main Methods:

  • A biodegradable, water-based poly(ester-urethane) was synthesized using isophorone diisocyanate/hydrazine and poly(caprolactone diol)/2,2-bis (hydroxymethyl) propionic acid.
  • Tensile strength and elongation-at-break were measured after degradation in synthetic urine.
  • In-body shape recovery was simulated and quantified in synthetic urine at body temperature.

Main Results:

  • The synthesized poly(ester-urethane) demonstrated shape recovery at body temperature in synthetic urine.
  • Material degradation was observed, indicated by changes in tensile strength and elongation-at-break.
  • Simulations suggested that combined hydrolytic attack and bladder wall compression could lead to sensor expulsion.

Conclusions:

  • Shape-memory polymers are a viable option for creating dynamic anchoring systems for bladder sensors.
  • The biodegradability and shape-recovery properties of the developed poly(ester-urethane) are suitable for this application.
  • Further in-vivo studies are warranted to confirm the safety and efficacy of the proposed anchoring system.