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Updated: Jun 5, 2026
The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
Published on: July 17, 2018
New diketopiperazine derivatives isolated from sea urchin-derived bacillus sp
Ken Yonezawa1, Koji Yamada, Isao Kouno
1Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyou-machi, Nagasaki, Japan.
Abstract:
Two new diketopiperazine derivatives, bacillusamides A (1) and B (2), have been isolated from the EtOAc extract of the sea urchin-derived Bacillus sp. along with the known cyclo(-L-pro-L-val-) (3), cyclo(-L-pro-L-tyr-) (4), cyclo(-L-pro-L-phe-) (5). These structures were elucidated by extensive spectroscopic methods. Furthermore, the absolute configurations of the amino acid residues were determined using Marfey's method. Compound 1 displayed weak antifungal activity against Aspergillus niger.
