[Study on the antitumor effects and synergism and attenuation effects of gecko alcohol extract]
Xiao-lan Wang1, Heng-you Hao, Jian-gang Wang
1Medical College, Henan University of Science and Technology, Luoyang 471003, China. wxl23@mail.haust.edu.cn
Objective:
To investigate the antitumor effects of Gecko alcohol extract and its synergism and attenuation effects on CTX.
Method:
S180-bearing mice were given Gecko alcohol extract via intravenous injection,the tumor inhibitory rate and the levels of serum TNF-alpha of mice were detected. After inoculation of S180 tumor, the synergism and attenuation effects of Gecko alcohol extract on CTX were observed. After 12 days treatment, the tumor inhibitory rate, the count of peripheral white blood cells, index of thymus and spleen were calculated.
Results:
Gecko alcohol extract in different dose (0.6, 1.2, 2.4 g/kg) inhibited the growth of S180 sarcoma in KM mice. The tumor inhibitory rates of 0.6, 1.2, 2.4 g/kg Gecko alcohol extract were 44.88%, 63.94%, 69.53%, respectively. However, the levels of serum TNF-alpha of mice not changed. The tumor inhibitory rates of intravenous administration of 0.6, 1.2, 2.4 g/ kg Gecko alcohol extract combined with CTX (20 mg/kg) were 56.93%, 67.15%, 70.24%, which were higher than that of CTX administration alone (41.71%). Compared with those in CTX group, the count of WBC (P < 0.01), the indexes of thymus and spleen (P < 0.05) were significantly elevated in all Gecko alcohol extract and CTX combination groups.
Conclusion:
Gecko alcohol extract has anti-tumor effects in vivo and attenuation effects on CTX.