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["Warming yang with pungent and sweet nature" compatibility of Guizhigancao Decoction]
Objective:
To investigate the pharmacodynamic action and the mechanism of the compatibility of "warming yang with pungent and sweet nature" function in Guizhigancao Decoction.
Methods:
SD rats were divided randomly into four groups:normal control group, guizhi group, gancao group, and guzhi-gancao group. The function of platelet aggregation and release, the contents of 6-keto-PEG1alpha, TXB, cAMP, cGMP and dissociative calcium ion were detected to verify the effects.
Results:
Guzhi-gancao group had obvious effects on inducing platelet aggregationby inhibiting ADP, decreasing both wet weight and dry weight of thrombus in vitro, increasing thrombosis and the contents of 6-keto-PEG1alpha and decreasing concentrations of cGMP and calcium ion.
Conclusion:
Compatibility of Guizhigancao Decoction can enhance the function of invigoration pulse beat through "warming yang with pungent and sweet nature".