Related Experiment Video

Updated: Jun 5, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

[Clinical and angiographic characteristics of mid-ventricular hypertrophic obstructive cardiomyopathy]

Chao-Wu Yan1, Shi-Hua Zhao, Hua Li

  • 1Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|January 11, 2011
PubMed

Insights

Mid-ventricular obstructive hypertrophic cardiomyopathy (MV-HOCM) is a distinct subtype. Cardiac catheterization and angiography are crucial for diagnosing MV-HOCM and guiding treatment.

Area of Science:

  • Cardiology
  • Cardiovascular Diseases
  • Medical Imaging

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is a complex condition.
  • Mid-ventricular obstruction presents a unique challenge in HOCM diagnosis and management.

Purpose of the Study:

  • To elucidate the clinical and angiographic features of mid-ventricular hypertrophic obstructive cardiomyopathy (MV-HOCM).
  • To establish MV-HOCM as a distinct entity within hypertrophic cardiomyopathy.

Main Methods:

  • Retrospective analysis of 5 patients diagnosed with MV-HOCM.
  • Comprehensive left ventricular catheterization and angiography, including pressure gradient measurements.
  • Electrocardiogram and coronary angiogram evaluations.

Main Results:

  • All patients exhibited mid-ventricular obstruction with significant pressure gradients (45–102 mm Hg).
  • Common clinical presentations included chest discomfort and syncope.
  • Characteristic findings included asymmetric left ventricular hypertrophy, systolic murmurs, and ECG abnormalities.
  • Associated conditions like left ventricular apical aneurysm were observed.

Conclusions:

  • MV-HOCM is a recognizable subtype of HOCM.
  • Left cardiac catheterization and angiography are essential diagnostic tools for MV-HOCM.
  • These investigations are vital for effective therapeutic guidance.
Abstract

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...