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Chemotaxis and Direction of Cell Migration

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

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Updated: Jun 5, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

[New prospects for chemokines].

William Rostène¹

¹Institue de la Vision INSERN-UPMC-CNRS 986, Paris, France.

Biologie Aujourd'Hui

|January 11, 2011

Summary

Chemokines, small proteins, regulate immune cells and are involved in development, cancer, and neurodegenerative diseases. This symposium introduces their diverse roles and basic properties.

Area of Science:

Immunology
Cell Biology
Neuroscience

Context:

Chemokines, initially known for immune cell attraction, are now recognized for broader roles.
These proteins and their receptors are expressed in various organs and cell types.
Their functions extend beyond immunity to development, oncology, and vascular processes.

Purpose:

To introduce the emerging field of chemokine research.
To highlight recent advances in understanding chemokine functions.
To examine the basic properties of chemokine systems and receptors.

Summary:

Chemokines are cytokines with chemoattractant properties for immune cells.
They play critical roles in infection, inflammation, stem cell migration, oncogenesis, neovascularization, atherosclerosis, and neuronal function.

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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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Last Updated: Jun 5, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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Chemokines are implicated in neurodegenerative diseases like Parkinson's and age-related macular degeneration, as well as pain.

Impact:

Provides a foundational understanding of chemokines for a broad audience.
Highlights the expanding roles of chemokines in diverse physiological and pathological processes.
Serves as an introduction to a symposium on chemokine research.