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Immunodiffusion test for serodiagnosing subcutaneous zygomycosis
L Kaufman1, L Mendoza, P G Standard
1Division of Mycotic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Journal of Clinical Microbiology
|September 1, 1990
Summary
This study identified specific antigens for Basidiobolus ranarum and Conidiobolus coronatus using immunodiffusion. The developed tests accurately detect basidiobolomycosis and conidiobolomycosis, aiding in diagnosis and infection monitoring.
Area of Science:
- Medical Mycology
- Immunology
Background:
- Basidiobolus ranarum and Conidiobolus coronatus are fungi causing zygomycosis.
- Accurate diagnostic methods are crucial for effective treatment.
Purpose of the Study:
- To identify specific antigens of B. ranarum and C. coronatus.
- To develop sensitive and specific immunodiffusion tests for diagnosing basidiobolomycosis and conidiobolomycosis.
Main Methods:
- Analysis of culture filtrate antigens using immunodiffusion (ID) with homologous rabbit antisera.
- Development of ID tests using specific precipitin bands as references.
- Testing with human and animal sera from confirmed cases and controls.
Main Results:
- B. ranarum and C. coronatus each possess five specific antigens.
- A shared antigen was detected among the species.
- The developed ID tests demonstrated complete sensitivity and specificity for diagnosing zygomycosis caused by these fungi.
- Tests showed utility in monitoring infection resolution.
Conclusions:
- Specific antigens for B. ranarum and C. coronatus were identified.
- Immunodiffusion tests provide a sensitive and specific diagnostic tool for basidiobolomycosis and conidiobolomycosis.
- These diagnostic tests can aid in monitoring treatment efficacy.