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Formulation design and optimization of fast disintegrating Lorazepam tablets by effervescent method
S B Shirsand1, Sarasija Suresh, L S Jodhana
1Department of Pharmaceutics, H.K.E. Society's College of Pharmacy, Sedam Road, Gulbarga - 585 104, India.
Indian Journal of Pharmaceutical Sciences
|January 11, 2011
Summary
Fast disintegrating lorazepam tablets were developed using an effervescent method. The optimized formulation significantly enhanced drug release, offering a promising alternative for improved patient compliance.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Patient compliance with oral medications can be improved through faster-dissolving dosage forms.
- Lorazepam is commonly prescribed, necessitating efficient delivery methods.
- Traditional tablets may exhibit slower dissolution and absorption rates.
Purpose of the Study:
- To develop fast-disintegrating lorazepam tablets utilizing an effervescent approach.
- To optimize the formulation by investigating the impact of crospovidone and effervescent material concentrations.
- To enhance in vitro dispersion time and drug release profiles for improved therapeutic efficacy.
Main Methods:
- A 3(2) full factorial design was employed to study formulation variables.
- Crospovidone (superdisintegrant) and an effervescent mixture (sodium bicarbonate, citric acid, tartaric acid) were key components.
- Tablets were evaluated for dispersion time, drug release, stability, and drug-excipient interactions.
Main Results:
- An optimized formulation with 8% crospovidone and 18% effervescent material achieved rapid dispersion (approx. 13 seconds).
- The optimized tablets demonstrated an eleven-fold faster drug release compared to conventional tablets (t(50%) 2.8 min vs. >30 min).
- Short-term stability studies showed no significant changes in drug content or dispersion time.
Conclusions:
- Fast-disintegrating lorazepam tablets prepared by the effervescent method offer significantly improved drug release.
- The optimized formulation enhances patient compliance due to rapid disintegration and faster absorption.
- This approach presents a viable strategy for developing advanced oral dosage forms with superior pharmacokinetic profiles.
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