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Separation of 90Y Microspheres and Imaging with PET/CT: Phantom Study
Özge Demir1, Emre Karayel2, Nami Yeyin2
1İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Engineering, Department of Chemical Engineering, İstanbul, Türkiye.
Objectives:
Yttrium 90 (90Y) microspheres are utilized in the treatment of liver tumors. This study aimed to prepare 90Y suitable for experimental studies by separating it from within the microspheres and imaging it cartographically in positron emission tomography/computed tomography (PET/CT).
Methods:
90Y microspheres were incubated for 2 hours in a solution containing 5.5 molar sodium chloride (NaCl) and 6 molar hydrochloric acid at pH 5. After this period, separation was achieved by passing through a 0.22 μm pore size polytetrafluoroethylene filter. A liver phantom, mimicking human liver equivalent dimensions and containing two simulated tumors, was filled with 90Y and imaged scintigraphically in PET/CT.
Results:
The true 90Y ratios between the large simulated tumor and the small simulated tumor compared to normal liver tissue were approximately 10:1 and 2:1, respectively. PET/CT images yielded these ratios as 11.3 and 2.13 for the large and small tumors, respectively. Homogeneous distribution of 90Y within the simulated liver tissue was observed.
Conclusion:
The separation technique enabled preparation of a homogeneous ionic 90Y solution suitable for quantitative PET/CT phantom imaging and may facilitate future phantom-based dosimetric studies.
