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Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
Published on: October 31, 2017
Palmitate puts ACLY in shape to reprogram macrophages
1Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Cell Reports
|October 5, 2026
Abstract:
Zhao et al.1 show that palmitate-driven ATP citrate lyase (ACLY) palmitoylation stabilizes nuclear ACLY tetramers, increases acetyl CoA production, and promotes pro-inflammatory macrophage programs. Targeting macrophage SCD1 with palmitate supplementation exploits this pathway to remodel the tumor microenvironment and suppress hepatocellular carcinoma.
