Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

Constitutive and Regulated Gene Expression

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...

Types of Genetic Transfer Between Organisms

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.

Types of Genetic Transfer Between Organisms

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Generation and use of renal cells for replacement therapies.

Current opinion in organ transplantation·2015

Same author

Underpinnings of cellular organ replacement therapies.

Current opinion in organ transplantation·2014

Same author

Classic and current opinion in embryonic organ transplantation.

Current opinion in organ transplantation·2014

Same author

Xenotransplantation of embryonic pig pancreas for treatment of diabetes mellitus in non-human primates.

Journal of biomedical science and engineering·2013

Same author

Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles.

Magnetic resonance in medicine·2013

Same author

Development of a novel xenotransplantation strategy for treatment of diabetes mellitus in rat hosts and translation to non-human primates.

Organogenesis·2012

Same journal

TRABD2A promotes osteogenic differentiation of human periodontal ligament stem cells by modulating TNF-α and IL-1β.

Organogenesis·2026

Same journal

Thyroid cancer-derived exosomal SPP1 promotes tumor progression by driving macrophage M2 polarization through the CD44/JAK2/STAT3 signaling pathway.

Organogenesis·2026

Same journal

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats.

Organogenesis·2026

Same journal

Adipose-derived mesenchymal stem cells-derived exosomes containing nano-pearl powder water-soluble matrix promote osteogenic differentiation of MC3T3-E1 cells.

Organogenesis·2026

Same journal

Comparison of vascular remodeling between a bioresorbable poly-L-lactic acid scaffold and a bare metal stent: a 6-month angiography and intravascular ultrasound analysis in porcine iliac arteries.

Organogenesis·2026

Same journal

Optimization of TX-100/SDS-based decellularized vascular material using ultrasound and chemical treatment: evaluation of structure and biosafety.

Organogenesis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Organogenetic tolerance.

Marc R Hammerman¹

¹Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mhammerm@dom.wustl.edu

|January 12, 2011

Summary

This summary is machine-generated.

Xenotransplantation using early embryonic pig pancreas can induce tolerance, potentially eliminating the need for immunosuppression in islet cell transplantation for diabetes. This organogenetic tolerance could revolutionize organ transplantation.

More Related Videos

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Area of Science:

Transplantation immunology
Xenotransplantation research
Diabetes mellitus therapeutics

Background:

Organ transplantation faces donor organ shortages and immunosuppression toxicity.
Xenotransplantation offers a potential solution to organ supply limitations.
Early embryonic tissues may possess reduced immunogenicity for transplantation.

Purpose of the Study:

To investigate the potential of early embryonic pig pancreas transplantation to induce tolerance to porcine islets.
To explore xenotransplantation as a strategy to overcome donor organ scarcity and immunosuppression issues in diabetes treatment.

Main Methods:

Transplantation of embryonic day 28 (E28) pig pancreatic primordia into diabetic rats and rhesus macaques.
Subsequent transplantation of adult porcine islets into rats previously receiving embryonic pig pancreas grafts.
Assessment of graft survival and host immune response without immunosuppression.

Main Results:

Long-term engraftment of insulin-producing cells from embryonic pig pancreas was achieved in non-immunosuppressed diabetic rats and rhesus macaques.
Rats previously transplanted with E28 pig pancreatic primordia showed successful engraftment of adult porcine islets.
These findings suggest the induction of "organogenetic tolerance" to porcine islet cells.

Conclusions:

Transplantation of early embryonic pig pancreas can induce a state of tolerance to subsequent adult porcine islet grafts.
This "organogenetic tolerance" may eliminate the need for host immune suppression in xenotransplantation of porcine islets for diabetes.
The methodology could be adapted for other embryonic organs, potentially revolutionizing transplantation therapy.