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Tailorable integrated optofluidic filters for biomolecular detection
Philip Measor1, Brian S Phillips, Aiqing Chen
1School of Engineering, University of CA Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Lab on a Chip
|January 12, 2011
Summary
This study introduces a novel optofluidic waveguide that acts as a spectral filter for advanced spectroscopy, enhancing signal-to-noise ratios for lab-on-chip devices.
Area of Science:
- Optofluidics
- Biophotonics
- Optical Engineering
Background:
- Spectral filters are crucial for biophotonic techniques like fluorescence and Raman spectroscopy.
- Integrating efficient spectral filters into lab-on-chip systems is essential for high sensitivity.
Purpose of the Study:
- To develop a novel optofluidic solution for spectral filtering within lab-on-chip devices.
- To integrate sample transport and spectral filtering functions into a single optical waveguide.
Main Methods:
- Exploited wavelength-dependent interference in antiresonant reflecting optical waveguides.
- Designed a liquid-core optical waveguide with three dielectric layers for spectral filtering.
- Demonstrated functionality for fluorescence and Förster resonance energy transfer detection.
Main Results:
- Achieved 37 dB extinction and a narrow 2.5 nm rejection band.
- Demonstrated a free spectral range of 76 nm.
- Increased signal-to-noise ratio by 18.4-fold for on-chip fluorescence detection.
Conclusions:
- The developed optofluidic waveguide effectively performs spectral filtering for advanced spectroscopy.
- This integration of fluidic and optical functions enables innovative, highly integrated lab-on-chip devices.
