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Related Concept Videos

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
Strain and Elastic Modulus01:15

Strain and Elastic Modulus

The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
Hooke's Law01:26

Hooke's Law

Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
Bending of Members Made of Several Materials01:11

Bending of Members Made of Several Materials

In analyzing a structural member composed of two different materials with identical cross-sectional areas, it is crucial to understand how their distinct elastic properties affect the member's response under load. The analysis involves assessing stress and strain distributions using the transformed section concept, which accounts for variations in material properties.
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each material's...
Dynamic Modulus of Elasticity of Concrete01:16

Dynamic Modulus of Elasticity of Concrete

The dynamic modulus of elasticity assesses how a concrete structure deforms under impact or dynamic loads. It is typically higher than the static modulus of elasticity, measured under slow, steady loading conditions.
The sonic test is a common method to determine the dynamic modulus. In this test, a concrete beam, sized either 6 x 6 x 30 inches or 4 x 4 x 20 inches, is clamped at its center. Vibrations are initiated at one end of the beam by an electromagnetic exciter unit powered by a...
Elasticity in Concrete01:20

Elasticity in Concrete

Upon subjecting concrete to moderate or high uniaxial compressive or tensile stresses, the strain response is non-linear relative to the stress applied. As the stress is removed, the resulting stress-strain curve deviates from the original path traced during loading, creating a hysteresis loop, indicative of the concrete's non-linear and non-elastic properties. Typically, a material's modulus of elasticity, which is a measure of the material's stiffness, is inferred from the linear portion of...

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Experimental and Data Analysis Workflow for Soft Matter Nanoindentation
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Published on: January 18, 2022

Characterization of cellular elastic modulus using structure based double layer model.

Yeongjin Kim1, Mina Kim, Jennifer H Shin

  • 1Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea. kim6224k@kaist.ac.kr

Medical & Biological Engineering & Computing
|January 12, 2011
PubMed
Summary
This summary is machine-generated.

This study developed a novel double-layered cellular model to more accurately measure the elastic modulus of liver cancer cells using atomic force microscopy. This advanced model overcomes limitations of previous methods for cell mechanics research.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Biomaterials

Background:

  • Cell mechanical properties are crucial for understanding cellular functions and disease.
  • Traditional models like Hertz-Sneddon (HS) have limitations in accurately characterizing complex cell structures.

Purpose of the Study:

  • To develop and validate a more accurate model for estimating the elastic modulus of hepatocellular carcinoma (HEP-G2) cells.
  • To overcome the limitations of the linear Hertz-Sneddon model for cell mechanical characterization.

Main Methods:

  • Utilized atomic force microscopy (AFM) to obtain force-displacement curves.
  • Developed a double-layered cellular (DLC) finite element model (FEM) considering cytoplasmic and nuclear layers.
  • Estimated nuclear elastic modulus using FEM after disrupting cytoskeletal networks and employed 3D confocal imaging for cellular dimensions.

Main Results:

  • The novel DLC model provides a more reliable estimation of cell elastic modulus compared to the HS model.
  • Results from the DLC model showed close correlation with experimental findings.
  • Successfully characterized the mechanical properties of HEP-G2 cells.

Conclusions:

  • The double-layered cellular (DLC) model offers improved accuracy in determining cell mechanical properties.
  • This approach enhances the understanding of liver cancer cell mechanics.
  • The developed model has potential applications in various cell mechanics studies.