Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet.

Molecular psychiatry·2014
Same author

Stability Of Default-Mode Network Activity In The Aging Brain.

Brain imaging and behavior·2009
Same author

I. Longitudinal changes in aging brain function.

Neurobiology of aging·2006
Same author

II. Temporal patterns of longitudinal change in aging brain function.

Neurobiology of aging·2006
Same author

Brain activation during encoding and recognition of verbal and figural information in older adults.

Neurobiology of aging·2004
Same author

Age-related differences in visual perception: a PET study.

Neurobiology of aging·2000
Same journal

The Role of Digital Health Technologies in Early Detection and Management of Alzheimer's Disease.

Current Alzheimer research·2026
Same journal

Quantifying Short-Term Functional Changes After Lecanemab Treatment in Early Alzheimer's Disease: An Exploratory 3-Month Follow-Up Case Report Using Eye Movement and Gait Analysis.

Current Alzheimer research·2026
Same journal

Corrigendum to: Advancing Alzheimer's Disease Diagnosis Using VGG19 and XGBoost: A Neuroimaging-Based Method.

Current Alzheimer research·2026
Same journal

Corrigendum to: Lithium Chloride Improves Electrophysiological and Memory Deficits in Rats with Streptozotocin-Induced Alzheimer's Disease.

Current Alzheimer research·2026
Same journal

Apolipoprotein E Mimetics in Targeted Drug Delivery: Advances and Therapeutic Potential for Neurodegenerative and Cardiovascular Diseases.

Current Alzheimer research·2026
Same journal

Association of Polymorphisms in Genes Involved in Serotonergic Signaling with the Risk of Developing Alzheimer's Disease.

Current Alzheimer research·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Dementia and the default mode.

L L Beason-Held1

  • 1National Institute on Aging, NIH, Baltimore, MD 21224-6825, USA. heldlo@mail.nih.gov

Current Alzheimer Research
|January 13, 2011
PubMed
Summary
This summary is machine-generated.

Default mode network (DMN) activity changes with aging and neurodegenerative diseases like Alzheimer's. Studying these brain network changes may link pathology to function, aiding in understanding cognitive decline.

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Related Experiment Videos

Last Updated: Jun 5, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Area of Science:

  • Neuroscience
  • Brain Aging Research
  • Cognitive Neurology

Background:

  • The default mode network (DMN) is crucial for resting-state brain function.
  • Age-related changes affect DMN activity, particularly in the medial frontal/anterior cingulate and posterior cingulate/precuneus.
  • Mild cognitive impairment (MCI) and Alzheimer's disease (AD) show distinct DMN alterations, especially in posterior regions and the hippocampus.

Purpose of the Study:

  • To investigate age-related alterations in DMN activity and connectivity.
  • To identify specific DMN changes associated with MCI and AD.
  • To explore the potential of DMN analysis in linking neuropathology to functional decline.

Main Methods:

  • Analysis of resting-state brain function.
  • Examination of regional activity levels within the DMN.
  • Assessment of network connectivity across the lifespan and in disease states.

Main Results:

  • DMN activity and connectivity exhibit significant changes throughout the lifespan.
  • Specific DMN regions, including the posterior cingulate/precuneus and hippocampus, are notably affected in normal aging and in MCI/AD.
  • These affected regions are also sites of known neuropathology in aging and disease.

Conclusions:

  • DMN functional changes are a hallmark of normal aging and neurodegenerative conditions.
  • The DMN's posterior cingulate/precuneus and hippocampal regions are critical areas for studying age-related functional decline.
  • Assessing DMN activity offers a promising avenue for understanding the structure-function relationship in the context of neuropathology.