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Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Related Experiment Video

Updated: Jun 5, 2026

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

Published on: May 14, 2014

NCI Image-Guided Drug Delivery Summit.

Pushpa Tandon¹, Keyvan Farahani

¹Cancer Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Cancer Research

|January 13, 2011

Summary

Image-guided drug delivery (IGDD) uses imaging for targeted cancer therapy. Overcoming biological barriers and optimizing nanocarrier systems are key challenges for clinical translation.

Area of Science:

Oncology
Nanotechnology
Medical Imaging

Background:

The NCI Image Guided Drug Delivery Summit convened experts to discuss advancements and challenges in IGDD for cancer.
Image-guided drug delivery (IGDD) aims to personalize cancer therapy by using imaging to guide and monitor targeted drug delivery to tumors.

Framework:

A systematic IGDD approach requires integrated mechanisms for targeting, drug delivery, activation, and process monitoring.
Optimizing the therapeutic ratio through personalized, image-guided treatments is the primary goal of IGDD.

Implementation:

Challenges to clinical translation of nano-based drug delivery systems include in vivo characterization, preclinical validation, and manufacturing scale-up.
Key areas for IGDD development include nanocarrier biodistribution, pharmacokinetics, pharmacodynamics, and toxicity studies.

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Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO

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Related Experiment Videos

Last Updated: Jun 5, 2026

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

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Published on: May 14, 2014

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

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Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO

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Published on: July 7, 2014

Implications:

Physiologic and quantitative imaging techniques are crucial enabling tools for advancing IGDD.
Addressing biological barriers to drug delivery presents opportunities for significant progress in personalized cancer treatment.