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Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes
Y Yamaguchi-Iwai1, M Satake, Y Murakami
1Department of Viral Oncology, Kyoto University, Japan.
Abstract:
The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.