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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...

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Updated: Jun 5, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein structure databases.

Roman A Laskowski1

  • 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. roman@ebi.ac.uk

Molecular Biotechnology
|January 13, 2011
PubMed
Summary
This summary is machine-generated.

This study reviews web-based protein structure databases, highlighting their diverse types and information content. Key resources include structural atlases, fold classification databases, and fold comparison servers for analyzing protein 3D structures and evolutionary relationships.

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Last Updated: Jun 5, 2026

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Web-based protein structure databases are essential resources in molecular biology.
  • These databases vary significantly in their scope and the depth of information provided.

Purpose of the Study:

  • To provide an overview of the landscape of web-based protein structure databases.
  • To categorize and describe the main types of protein structure databases and their applications.

Main Methods:

  • Review and categorization of existing web-based protein structure databases.
  • Analysis of the types of information and functionalities offered by different databases.

Main Results:

  • Identification of general interest databases including structural atlases, fold classification databases, and fold comparison servers.
  • Recognition of specialized databases catering to specific research needs, such as protein families or diseases.

Conclusions:

  • Protein structure databases offer diverse tools for exploring 3D structures, biological functions, and evolutionary relationships.
  • The choice of database depends on the specific research question, from general structural analysis to specialized investigations.