Ring B aromatic norpimarane glucoside from a Xylaria sp

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Mycology

Background:

• Fungi are a rich source of diverse bioactive natural products.
• The genus Xylaria is known to produce various secondary metabolites with potential biological activities.

Purpose of the Study:

• To isolate and characterize novel compounds from the fungus Xylaria sp. BCC 4297.
• To evaluate the cytotoxic activity of isolated compounds against human cancer cell lines.

Main Methods:

• Chemical isolation and structure elucidation of compounds from fungal extracts.
• In vitro cytotoxicity assays using cancer cell lines (KB, MCF-7, NCI-H187).

Main Results:

• A novel 20-norpimarane glucoside, xylopimarane (1), was identified.
• Known compounds sphaeropsidin C (2) and clonostachydiol (3) were also isolated.
• Xylopimarane (1) exhibited potent cytotoxicity against KB (IC50 = 1.0 μM), MCF-7 (IC50 = 13 μM), and NCI-H187 (IC50 = 65 μM) cancer cell lines.

Conclusions:

• Xylopimarane is a novel cytotoxic compound isolated from Xylaria sp.
• The findings suggest xylopimarane as a potential lead compound for anticancer drug development.